Tolerance to tacrine, arterial hypotension and leuko-araiosis in Alzheimer's disease
نویسندگان
چکیده
منابع مشابه
The presence of leuko-araiosis in patients with Alzheimer's disease predicts poor tolerance to tacrine, but does not discriminate responders from non-responders.
BACKGROUND approximately one-third of patients with Alzheimer's disease (AD) respond favourably to the anticholinesterase tacrine, but the drug's usefulness is marred by a high incidence of side-effects. OBJECTIVE to discover if AD patients with white matter low attenuation (WMLA) represents a subgroup that responds differently to tacrine from those with no WMLA. DESIGN the results come fro...
متن کاملClinical features of leuko-araiosis.
OBJECTIVE To study the clinical features of leuko-araiosis. METHODS Age matched groups of patients with a CT finding of pure leukoaraiosis (n = 26) and a control group with a normal CT finding (n = 26) were formed (mean ages 78.6 (SD 3.3) v 76.5 (SD 4.6) years; NS). RESULTS Dementia, vascular dementia, central brain atrophy on CT, disability in activities of daily living and instrumental ac...
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We report on silent brain infarction (SBI) and leukoaraiosis (LA) of 23 patients with clinically diagnosed “first-ever” acute ischemic lacunar stroke. The lacunar syndromes were pure motor hemiparesis (10), pure sensory syndrome (2), ataxic hemiparesis (3), dysarthria clumsy hand syndrome (3), and sensorymotor deficit (5). Nineteen out of the 23 patients presented with completed strokes on arri...
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CT images of leuko-araiosis in brain slices were quantified according to volumes of reduced Hounsfield units in frontal periventricular white matter in groups of elderly patients with multi-infarct dementia (MID, n = 23) and dementia of the Alzheimer type (DAT, n = 16). Volumes of leuko-araiosis, estimates of atrophic cerebral tissue, and local cerebral perfusion utilising inhalation of xenon g...
متن کاملDifferences in regional cerebral blood flow in two types of leuko-araiosis.
Cerebral blood flow and cerebrovascular acetazolamide reactivity were investigated in patients with periventricular hyperintensity and in patients with leuko-araiosis in centrum semiovale. Fifteen patients with periventricular hyperintensity, 15 patients with leuko-araiosis in centrum semiovale and 15 age-matched controls without leuko-araiosis were studied. The regional cerebral blood flow was...
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ژورنال
عنوان ژورنال: Age and Ageing
سال: 1998
ISSN: 0002-0729,1468-2834
DOI: 10.1093/ageing/27.5.654